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  • Superoxide Dismutase - an overview

    In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. General information. Orgotein, an enzyme (CuZn superoxide dismutase) that is present in all mammalian cells, is obtained from bovine liver by several steps, including chromatography.It can be given parenterally or topically and has been used to treat conditions such as radiation cystitis [1–7], osteoarthritis [8–11], and Peyronie ...

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  • The structural biochemistry of the superoxide dismutases

    2021-7-24u2002·u20023. Cu,ZnSOD. In 1938, Mann and Keilin [] isolated a bovine erythrocyte protein with a blue color contributed by bound copper.They termed the ~31.5 kDa protein hemocuprein. In the 1950s, human homologues of erythrocuprein were isolated from erythrocytes [70,71] and perhaps more pertinent to ALS, cerebrocuprein from the brain [].In 1969, 30 years after the initial isolation, McCord and Fridovich ...

    Get Price
  • Superoxide Dismutase - an overview

    Superoxide dismutase (SOD) is a primary enzyme in the defensive system against oxidative stress and is elicited to reduce the effect of superoxide radicals. Exposure to ethanol decreases total SOD activity levels in PSCs ( Figure 108.5 A) with paradoxical increases in the gene expression of Mn- and Cu/Zn-SOD ( Figure 108.5 B, C).

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  • Superoxide dismutase undergoes proteolysis and ...

    Red blood cells (RBC) are thought to be well protected against oxidative stress by the antioxidant, cu-pro-zinc enzyme superoxide dismutase (CuZn SOD) which dismutates O2- to H2O2. CuZn SOD, however, is irreversibly inactivated by its product H2O2. Exposure of intact RBC to H2O2 resulted in the inac …

    Get Price
  • (PDF) Superoxide and superoxide dismutase

    Sedimentation velocity schlieren patterns of bovine superoxide dismutase. ml in 0.1 Y NaCl buffered at pH 7.0 with potassium phosphate. Protein concentration was 7.35 mg per

    Get Price
  • Extracellular Superoxide Dismutase: Growth Promoter or ...

    2016-5-12u2002·u2002Extracellular superoxide dismutase (SOD3) gene transfer to tissue damage results in increased healing, increased cell proliferation, decreased apoptosis, and decreased inflammatory cell infiltration. At molecular level, in vivo SOD3 overexpression reduces superoxide anion () concentration and increases mitogen kinase activation suggesting that ...

    Get Price
  • The Aktâ FoxO3aâ manganese superoxide dismutase

    cell growth and cell survival. Phosphoinositide 3-kinase phosphorylates and activates Akt. Activated Akt can phosphorylate several downstream proteins, including Glycogen Synthase Kinase 3-β, Forkhead (FoxO) transcription factors and tuberous sclerosis 1 and 2, to control cell growth, cell survival and protein synthesis (Garcia et al.2006; Kim ...

    Get Price
  • Superoxide dismutases: Dual roles in controlling ROS ...

    Chemically, the dismutase activity of SODs accelerates the reaction of the superoxide anion (O 2 •−) with itself to form hydrogen peroxide (H 2 O 2) and oxygen (2O 2 •− +2H + → H 2 O 2 +O 2; Fridovich, 1997).Superoxide is a negatively charged free radical formed through a single electron donation to oxygen (Hayyan et al., 2016).It is only moderately reactive by itself (Winterbourn ...

    Get Price
  • Automated Assays for Superoxide Dismutase, Catalase ...

    ANALYTICALBIOCHEMISTRY 184,193-l% (1990) Automated Assays for Superoxide Dismutase, Catalase, Glutathione Peroxidase, and Glutathione Reductase Activity'

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  • Extracellular Superoxide Dismutase: Growth Promoter or ...

    2016-5-12u2002·u2002Extracellular superoxide dismutase (SOD3) gene transfer to tissue damage results in increased healing, increased cell proliferation, decreased apoptosis, and decreased inflammatory cell infiltration. At molecular level, in vivo SOD3 overexpression reduces superoxide anion () concentration and increases mitogen kinase activation suggesting that ...

    Get Price
  • Superoxide dismutase-3 promotes full expression of the

    2004-7-1u2002·u2002To maintain O 2 homeostasis, a number of genes are up-regulated at low O 2 tension via signaling that activates transcription (eg, via hypoxia-inducible transcription factor 1 [HIF-1]). HIF-1 is crucial in sensing hypoxia and integrating the adaptive response via transcription of O 2-sensitive genes. 12,13 The physiologic factors that link O 2 availability to transcription relate broadly to ...

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  • SOD1 - Superoxide dismutase [Cu-Zn] - Bos taurus (Bovine ...

    2007-1-23u2002·u2002positive regulation of catalytic activity Source: UniProtKB. Inferred from direct assay i. 'Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo.' Agbas …

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  • Extracellular superoxide dismutase protects Histoplasma ...

    2012-5-17u2002·u2002We show that Histoplasma yeasts produce a superoxide dismutase (Sod3) and direct it to the extracellular environment via N-terminal and C-terminal signals which promote its secretion and association with the yeast cell surface. This localization permits Sod3 to protect yeasts specifically from exogenous superoxide whereas amelioration of ...

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  • Extracellular Superoxide Dismutase Protects Histoplasma ...

    The Histoplasma SOD3 gene encodes an extracellular superoxide dismutase. Proteomic analysis of the extracellular proteins produced by pathogenic-phase Histoplasma cells identified a putative superoxide dismutase .The gene encoding this protein was designated SOD3 to distinguish it from the intracellular Sod proteins, Sod1, Sod2, and Sod4. The SOD3 locus contains a 771 base pair gene comprised ...

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  • Fc-Receptor-Mediated Intracellular Delivery of Cu/Zn ...

    2000-12-1u2002·u2002Using specific antibodies against bovine Cu/Zn-superoxide dismutase (EC 1.15.1.1, SOD1) we demonstrated that anti-SOD antibodies (IgG1) are able to promote the intracellular translocation of the antioxidant enzyme. The transduction signalling mediated by IgG1 immune complexes are known to promote a concomitant production of superoxide and nitric oxide leading to the production of ...

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  • Frontiers

    2020-5-12u2002·u2002Superoxide dismutase is widespread in the human body, including skin and its appendages. Here, we focus on human skin copper/zinc superoxide dismutase, the enzyme that protects skin and its appendages against reactive oxygen species. Human skin copper/zinc superoxide dismutase resides in the cytoplasm of keratinocytes, where up to 90% of cellular reactive oxygen species is produced.

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  • Cellular and Molecular Deviations in Bovine In Vitro ...

    Introduction. Bovine in vitro-produced (IVP) embryos display numerous marked differences from their in vivo-derived counterparts with regard to morphology [], timing of development [], resistance to low temperature [3, 4], embryonic metabolism [], and gene expression [].The large offspring syndrome (LOS) has been observed in bovine and ovine offspring following transfer of IVP or cloned ...

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  • Potential anti-aging effects of fermented wheat germ in ...

    2021-8-1u2002·u20021. Introduction. Twelve percent of the world's population consists of people aged 60 and above in 2016; it is expected to increase to 22% by 2050 (Wasay et al., 2016).This suggests that the population is aging rapidly (Chang et al., 2019).Aging is the degeneration of the human body, physiology and metabolic processes (Franceschi et al., 2018).A number of diseases are related to aging such as ...

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  • The Protective Effect of a Metallic Selenopeptide with ...

    2014-2-15u2002·u2002A 65-mer peptide (Se–CuZn–65P) is an enzyme mimic with antioxidant activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX). The metallic selenopeptide imitate was obtained through a single protein production system and cysteine auxotrophic expression technique, and it enters cells in the assistance of the trans-activator of transcription peptide. Because Se–CuZn–65P was ...

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  • Superoxide Dismutase - an overview

    In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. General information. Orgotein, an enzyme (CuZn superoxide dismutase) that is present in all mammalian cells, is obtained from bovine liver by several steps, including chromatography.It can be given parenterally or topically and has been used to treat conditions such as radiation cystitis [1–7], osteoarthritis [8–11], and Peyronie ...

    Get Price
  • The structural biochemistry of the superoxide dismutases

    2021-7-24u2002·u20023. Cu,ZnSOD. In 1938, Mann and Keilin [] isolated a bovine erythrocyte protein with a blue color contributed by bound copper.They termed the ~31.5 kDa protein hemocuprein. In the 1950s, human homologues of erythrocuprein were isolated from erythrocytes [70,71] and perhaps more pertinent to ALS, cerebrocuprein from the brain [].In 1969, 30 years after the initial isolation, McCord and Fridovich ...

    Get Price
  • Superoxide Dismutase - an overview

    Superoxide dismutase (SOD) is a primary enzyme in the defensive system against oxidative stress and is elicited to reduce the effect of superoxide radicals. Exposure to ethanol decreases total SOD activity levels in PSCs ( Figure 108.5 A) with paradoxical increases in the gene expression of Mn- and Cu/Zn-SOD ( Figure 108.5 B, C).

    Get Price
  • Superoxide dismutase undergoes proteolysis and ...

    Red blood cells (RBC) are thought to be well protected against oxidative stress by the antioxidant, cu-pro-zinc enzyme superoxide dismutase (CuZn SOD) which dismutates O2- to H2O2. CuZn SOD, however, is irreversibly inactivated by its product H2O2. Exposure of intact RBC to H2O2 resulted in the inac …

    Get Price
  • (PDF) Superoxide and superoxide dismutase

    Sedimentation velocity schlieren patterns of bovine superoxide dismutase. ml in 0.1 Y NaCl buffered at pH 7.0 with potassium phosphate. Protein concentration was 7.35 mg per

    Get Price
  • Extracellular Superoxide Dismutase: Growth Promoter or ...

    2016-5-12u2002·u2002Extracellular superoxide dismutase (SOD3) gene transfer to tissue damage results in increased healing, increased cell proliferation, decreased apoptosis, and decreased inflammatory cell infiltration. At molecular level, in vivo SOD3 overexpression reduces superoxide anion () concentration and increases mitogen kinase activation suggesting that ...

    Get Price
  • The Aktâ FoxO3aâ manganese superoxide dismutase

    cell growth and cell survival. Phosphoinositide 3-kinase phosphorylates and activates Akt. Activated Akt can phosphorylate several downstream proteins, including Glycogen Synthase Kinase 3-β, Forkhead (FoxO) transcription factors and tuberous sclerosis 1 and 2, to control cell growth, cell survival and protein synthesis (Garcia et al.2006; Kim ...

    Get Price
  • Superoxide dismutases: Dual roles in controlling ROS ...

    Chemically, the dismutase activity of SODs accelerates the reaction of the superoxide anion (O 2 •−) with itself to form hydrogen peroxide (H 2 O 2) and oxygen (2O 2 •− +2H + → H 2 O 2 +O 2; Fridovich, 1997).Superoxide is a negatively charged free radical formed through a single electron donation to oxygen (Hayyan et al., 2016).It is only moderately reactive by itself (Winterbourn ...

    Get Price
  • Automated Assays for Superoxide Dismutase, Catalase ...

    ANALYTICALBIOCHEMISTRY 184,193-l% (1990) Automated Assays for Superoxide Dismutase, Catalase, Glutathione Peroxidase, and Glutathione Reductase Activity'

    Get Price
  • Mesenchymal stem cell‐secreted superoxide dismutase ...

    Mesenchymal stem cells secrete superoxide dismutase 3. In order to define precisely the soluble factors which may be involved in cerebellar neuroprotection mediated by MSCs, MSC conditioned medium was subjected to two‐dimensional (2D) SDS–PAGE and Sypro Ruby staining.

    Get Price
  • Superoxide Dismutase - an overview

    In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. General information. Orgotein, an enzyme (CuZn superoxide dismutase) that is present in all mammalian cells, is obtained from bovine liver by several steps, including chromatography.It can be given parenterally or topically and has been used to treat conditions such as radiation cystitis [1–7], osteoarthritis [8–11], and Peyronie ...

    Get Price
  • The structural biochemistry of the superoxide dismutases

    2021-7-24u2002·u20023. Cu,ZnSOD. In 1938, Mann and Keilin [] isolated a bovine erythrocyte protein with a blue color contributed by bound copper.They termed the ~31.5 kDa protein hemocuprein. In the 1950s, human homologues of erythrocuprein were isolated from erythrocytes [70,71] and perhaps more pertinent to ALS, cerebrocuprein from the brain [].In 1969, 30 years after the initial isolation, McCord and Fridovich ...

    Get Price
  • Superoxide Dismutase - an overview

    Superoxide dismutase (SOD) is a primary enzyme in the defensive system against oxidative stress and is elicited to reduce the effect of superoxide radicals. Exposure to ethanol decreases total SOD activity levels in PSCs ( Figure 108.5 A) with paradoxical increases in the gene expression of Mn- and Cu/Zn-SOD ( Figure 108.5 B, C).

    Get Price
  • Superoxide dismutase undergoes proteolysis and ...

    Red blood cells (RBC) are thought to be well protected against oxidative stress by the antioxidant, cu-pro-zinc enzyme superoxide dismutase (CuZn SOD) which dismutates O2- to H2O2. CuZn SOD, however, is irreversibly inactivated by its product H2O2. Exposure of intact RBC to H2O2 resulted in the inac …

    Get Price
  • (PDF) Superoxide and superoxide dismutase

    Sedimentation velocity schlieren patterns of bovine superoxide dismutase. ml in 0.1 Y NaCl buffered at pH 7.0 with potassium phosphate. Protein concentration was 7.35 mg per

    Get Price
  • Extracellular Superoxide Dismutase: Growth Promoter or ...

    2016-5-12u2002·u2002Extracellular superoxide dismutase (SOD3) gene transfer to tissue damage results in increased healing, increased cell proliferation, decreased apoptosis, and decreased inflammatory cell infiltration. At molecular level, in vivo SOD3 overexpression reduces superoxide anion () concentration and increases mitogen kinase activation suggesting that ...

    Get Price
  • The Aktâ FoxO3aâ manganese superoxide dismutase

    cell growth and cell survival. Phosphoinositide 3-kinase phosphorylates and activates Akt. Activated Akt can phosphorylate several downstream proteins, including Glycogen Synthase Kinase 3-β, Forkhead (FoxO) transcription factors and tuberous sclerosis 1 and 2, to control cell growth, cell survival and protein synthesis (Garcia et al.2006; Kim ...

    Get Price
  • Superoxide dismutases: Dual roles in controlling ROS ...

    Chemically, the dismutase activity of SODs accelerates the reaction of the superoxide anion (O 2 •−) with itself to form hydrogen peroxide (H 2 O 2) and oxygen (2O 2 •− +2H + → H 2 O 2 +O 2; Fridovich, 1997).Superoxide is a negatively charged free radical formed through a single electron donation to oxygen (Hayyan et al., 2016).It is only moderately reactive by itself (Winterbourn ...

    Get Price
  • Automated Assays for Superoxide Dismutase, Catalase ...

    ANALYTICALBIOCHEMISTRY 184,193-l% (1990) Automated Assays for Superoxide Dismutase, Catalase, Glutathione Peroxidase, and Glutathione Reductase Activity'

    Get Price
  • Mesenchymal stem cell‐secreted superoxide dismutase ...

    Mesenchymal stem cells secrete superoxide dismutase 3. In order to define precisely the soluble factors which may be involved in cerebellar neuroprotection mediated by MSCs, MSC conditioned medium was subjected to two‐dimensional (2D) SDS–PAGE and Sypro Ruby staining.

    Get Price
  • Extracellular Superoxide Dismutase Is a Growth Regulatory ...

    2009-3-1u2002·u2002Extracellular superoxide dismutase (SOD3) gene therapy has been shown to attenuate tissue damages and to improve the recovery of the tissue injuries, but the cellular events delivering the therapeutic response of the enzyme are not well defined. In the current work, we overexpressed SOD3 in rat hindlimb ischemia model to study the signal transduction and injury healing following the sod3 gene ...

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  • Superoxide Dismutase 3 R213G Single-Nucleotide ...

    2021-8-31u2002·u2002Idiopathic pulmonary fibrosis (IPF) is an incurable and fatal disease in humans (), characterized by significant lung fibrosis and lung oxidative stress (2, 3).Patients with IPF are also at risk of developing secondary pulmonary hypertension (PH), which worsens outcomes ().Although the etiology of IPF is incompletely understood, there is strong evidence that lung inflammation, together with ...

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  • Insights into superoxide dismutase 3 ... - Cell & Bioscience

    2020-2-27u2002·u2002Mesenchymal stem cells (MSCs) have been extensively studied and implicated for the cell-based therapy in several diseases due to theirs immunomodulatory properties. Embryonic stem cells and induced-pluripotent stem cells have either ethical issues or concerns regarding the formation of teratomas, introduction of mutations into genome during prolonged culture, respectively which limit …

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  • Superoxide dismutase - MARKLUND; STEFAN

    1990-8-27u2002·u2002A superoxide dismutase originally found in extracellular body fluids and therefore termed extracellular superoxide dismutase (EC-SOD) is prepared by growing a cell line, preferably of mammalian origin, producing EC-SOD and recovering the EC-SOD secreted from the cells or by inserting a DNA sequence encoding EC-SOD into a suitable vector, introducing the recombinant vector into a host cell ...

    Get Price
  • A novel process for the recovery of superoxide dismutase ...

    Research Article Received: 6 September 2012 Revised: 24 October 2012 Accepted: 26 October 2012 Published online in Wiley Online Library: (wileyonlinelibrary.com) DOI 10.1002/jctb.3993 A novel process for the recovery of superoxide dismutase from yeast exploiting electroextraction coupled to direct sorption† ´ Simental-Mart´ınez,a,b Rami Reddy Vennapusa,a Jorge Benavides,b Jesus Valentina ...

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  • Effect of vitamin A treatment on superoxide dismutase ...

    2010-2-4u2002·u2002Vitamin A (Vit A) is widely suggested to be protective against oxidative stress. However, different studies have been demonstrated the pro-oxidant effects of retinoids in several experimental models. In this work, we used the yeast Saccharomyces cerevisiae as a model organism to study the Vit A effects on superoxide dismutase (SOD)-deficient yeast strains. We report here that Vit A (10, 20 and ...

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  • Mitochondrial Manganese-Superoxide Dismutase

    Superoxide dismutases (SODs) are important antioxidant enzymes responsible for the elimination of superoxide radical (O2−). The manganese-containing SOD (Mn-SOD) has been suggested to have tumor suppressor function and is located in the mitochondria where the majority of O2− is generated during respiration. Although increased reactive oxygen species (ROS) in cancer cells has long been ...

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  • The Role of Manganese Superoxide Dismutase in Skin

    2011-3-23u2002·u2002Recent studies have shown that antioxidant enzyme expression and activity are drastically reduced in most human skin diseases, leading to propagation of oxidative stress and continuous disease progression. However, antioxidants, an endogenous defense system against reactive oxygen species (ROS), can be induced by exogenous sources, resulting in protective effects against associated …

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  • Nitric oxide is the primary mediator of cytotoxicity ...

    The effect of BSO on cell growth and viability was analyzed by direct count by Trypan Blue staining. We found that, after 24 hours, BSO profoundly affected cell number ( Fig. 1B ) without any increase in dead cells ( Fig. 1C ), indicating that proliferation arrest was occurring.

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  • Thiamine and selected thiamine antivitamins — biological ...

    Thiamine plays a very important coenzymatic and non-coenzymatic role in the regulation of basic metabolism. Thiamine diphosphate is a coenzyme of many enzymes, most of which occur in prokaryotes. Pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes as well as transketolase are the examples of thiamine-dependent enzymes present in eukaryotes, including human. Therefore, …

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  • Superoxide Dismutase (SOD) Detection Kit

    Product Description Superoxide dismutase (SOD), which catalyzes the dismutation of the superoxide anion (O 2.-) into hydrogen peroxide and molecular oxygen, is one of the most important antioxidative enzymes.In mammals, cytosolic SOD has a greenish color and consists of two subunits, one containing copper and the other zinc (Cu/Zn-SOD).

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  • Secretion of Extracellular Superoxide Dismutase From ...

    A number of reports have described the effects of oxidative stress on tumor growth. Therefore, these experiments were designed to test the hypothesis that overexpression of extracellular superoxide dismutase (ecSOD) would inhibit the growth of tumors arising from s.c. implantation of syngenic B16-F1 melanoma cells. C57BL/6 mice were infected i.m. with adenovirus containing either β ...

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  • Measurement of superoxide dismutase, catalase and ...

    2009-12-17u2002·u2002Ough, M. et al. Inhibition of cell growth by overexpression of manganese superoxide dismutase (MnSOD) in human pancreatic carcinoma. Free Radic. Res. 38, 1223–1233 (2004).

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  • Superoxide dismutase - Symbicom Aktiebolag

    1993-9-24u2002·u2002A superoxide dismutase originally found in extracellular body fluids and therefore termed extracellular superoxide dismutase (EC-SOD) is prepared by growing a cell line, preferably of mammalian origin, producing EC-SOD and recovering the EC-SOD secreted from the cells or by inserting a DNA sequence encoding EC-SOD into a suitable vector, introducing the recombinant vector into a host cell ...

    Get Price
  • SOD1 - Superoxide dismutase [Cu-Zn] - Function

    Here, we show that in vitro Cu,Zn-superoxide dismutase (SOD1) fibrils are transduced into cells and function as seeds to trigger the aggregation of endogenously expressed SOD1. Seeded aggregation of mutant SOD1 will thus play roles in a molecular pathomechanism of …

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  • The Interstitium of the Human Arterial Wall Contains Very ...

    1995-11-1u2002·u2002Abstract The levels of the secreted, interstitially located extracellular superoxide dismutase (EC-SOD), the cytosolic copper-and-zinc–containing SOD (CuZn-SOD), and the mitochondrial manganese-containing SOD (Mn-SOD) were measured in the walls of human coronary arteries, proximal thoracic aortas, and saphenous veins.The blood vessel walls, particularly the arteries, were found to …

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  • Switch of Mitochondrial Superoxide Dismutase into a ... - Cell

    Superoxide radical anion (O 2 ⋅‒) and other reactive oxygen species are constantly produced during respiration.In mitochondria, the dismutation of O 2 ⋅‒ is accelerated by the mitochondrial superoxide dismutase 2 (SOD2), an enzyme that has been traditionally associated with antioxidant protection. However, increases in SOD2 expression promote oxidative stress, indicating that there may ...

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  • The iron-dependent mitochondrial superoxide dismutase

    2017-7-21u2002·u2002Leishmaniasis is one of the leading globally neglected diseases, affecting millions of people worldwide. Leishmania infection depends on the ability of insect-transmitted metacyclic promastigotes to invade mammalian hosts, differentiate into amastigotes, and replicate inside macrophages. To counter the hostile oxidative environment inside macrophages, these protozoans contain anti-oxidant ...

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  • Thiamine and selected thiamine antivitamins — biological ...

    Thiamine plays a very important coenzymatic and non-coenzymatic role in the regulation of basic metabolism. Thiamine diphosphate is a coenzyme of many enzymes, most of which occur in prokaryotes. Pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes as well as transketolase are the examples of thiamine-dependent enzymes present in eukaryotes, including human. Therefore, …

    Get Price
  • Toxicity of antimony, copper, cobalt, manganese, titanium ...

    2016-10-19u2002·u2002The cells were seeded to a 96-well plate in concentrations of 1 × 10 4 cells per well for Caco2 cells or 0.5 × 10 4 per well for A549 and Balb/c 3T3 cells. After 24 h of growth (95 % humidity, 37 °C, 5 % CO 2) the cells were exposed to NPs using concentrations 3–100 μg metal/mL.

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