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  • The structural biochemistry of the superoxide dismutases

    2021-7-24u2002·u20023. Cu,ZnSOD. In 1938, Mann and Keilin [] isolated a bovine erythrocyte protein with a blue color contributed by bound copper.They termed the ~31.5 kDa protein hemocuprein. In the 1950s, human homologues of erythrocuprein were isolated from erythrocytes [70,71] and perhaps more pertinent to ALS, cerebrocuprein from the brain [].In 1969, 30 years after the initial isolation, McCord and Fridovich ...

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  • Extracellular Superoxide Dismutase: Growth Promoter or ...

    2016-5-12u2002·u2002Extracellular superoxide dismutase (SOD3) gene transfer to tissue damage results in increased healing, increased cell proliferation, decreased apoptosis, and decreased inflammatory cell infiltration. At molecular level, in vivo SOD3 overexpression reduces superoxide anion () concentration and increases mitogen kinase activation suggesting that ...

    Get Price
  • Effect of dietary bovine lactoferrin on lipid peroxidation ...

    The technology of producing bovine lactoferrin on a factory scale was established over 20 years ago. ... A method is described for the estimation of red cell superoxide dismutase (erythrocuprein ...

    Get Price
  • 6647 - Gene ResultSOD1 superoxide dismutase 1 [ (human)]

    2021-10-31u2002·u2002The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein.

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  • Evaluation of Superoxide Dismutase Enzyme Activity of ...

    2021-7-13u2002·u2002growth, mutagenesis and cell death, the critical damaging effects being on DNA and enzymes. 4 The antioxidant system includes enzymatic and non-enzymatic antioxidant components. Superoxide dismutase (SOD), one of the main antioxidant enzymes, catalyses the dismutation of highly reactive superoxide anions to hydrogen peroxide, a

    Get Price
  • The Aktâ FoxO3aâ manganese superoxide dismutase

    cell growth and cell survival. Phosphoinositide 3-kinase phosphorylates and activates Akt. Activated Akt can phosphorylate several downstream proteins, including Glycogen Synthase Kinase 3-β, Forkhead (FoxO) transcription factors and tuberous sclerosis 1 and 2, to control cell growth, cell survival and protein synthesis (Garcia et al.2006; Kim ...

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  • Superoxide Dismutases: Role in Redox Signaling, Vascular ...

    2011-9-15u2002·u2002Generation and metabolism of reactive oxygen species (ROS). Superoxide (O 2 •−) is produced by NADPH oxidase, xanthine oxidase, nitric oxide synthase (NOS), lipoxygenase, and mitochondrial enzymes.Superoxide is converted by superoxide dismutase (SOD) to H 2 O 2, which, in turn, is reduced to water by catalase, glutathione peroxidases (GPx), and peroxiredoxins (Prx).

    Get Price
  • Vascular endothelial growth factor induces manganese ...

    2001-9-17u2002·u2002Vascular endothelial growth factor (VEGF) is a potent vascular endothelial cell-specific mitogen that modulates endothelial cell function. In the present study, we show that VEGF induces manganese-superoxide dismutase (MnSOD) mRNA and protein in human coronary artery endothelial cells (HCAEC) and pulmonary artery endothelial cells.

    Get Price
  • β-Lactoglobulin Heptapeptide Reduces Oxidative Stress in ...

    2019-11-12u2002·u2002Peptides derived from buffalo dairy products possess multiple healthy properties that cannot be exerted as long as they are encrypted in parent proteins. To evaluate the biological activities of encrypted peptide sequences from buffalo ricotta cheese, we performed a simulated gastrointestinal (GI) digestion. Chemical and pharmacological characterization of the digest led to the identification ...

    Get Price
  • The structural biochemistry of the superoxide dismutases

    2021-7-24u2002·u20023. Cu,ZnSOD. In 1938, Mann and Keilin [] isolated a bovine erythrocyte protein with a blue color contributed by bound copper.They termed the ~31.5 kDa protein hemocuprein. In the 1950s, human homologues of erythrocuprein were isolated from erythrocytes [70,71] and perhaps more pertinent to ALS, cerebrocuprein from the brain [].In 1969, 30 years after the initial isolation, McCord and Fridovich ...

    Get Price
  • Extracellular Superoxide Dismutase: Growth Promoter or ...

    2016-5-12u2002·u2002Extracellular superoxide dismutase (SOD3) gene transfer to tissue damage results in increased healing, increased cell proliferation, decreased apoptosis, and decreased inflammatory cell infiltration. At molecular level, in vivo SOD3 overexpression reduces superoxide anion () concentration and increases mitogen kinase activation suggesting that ...

    Get Price
  • Effect of dietary bovine lactoferrin on lipid peroxidation ...

    The technology of producing bovine lactoferrin on a factory scale was established over 20 years ago. ... A method is described for the estimation of red cell superoxide dismutase (erythrocuprein ...

    Get Price
  • Evaluation of Superoxide Dismutase Enzyme Activity of ...

    2021-7-13u2002·u2002growth, mutagenesis and cell death, the critical damaging effects being on DNA and enzymes. 4 The antioxidant system includes enzymatic and non-enzymatic antioxidant components. Superoxide dismutase (SOD), one of the main antioxidant enzymes, catalyses the dismutation of highly reactive superoxide anions to hydrogen peroxide, a

    Get Price
  • Superoxide Dismutases: Role in Redox Signaling, Vascular ...

    2011-9-15u2002·u2002Generation and metabolism of reactive oxygen species (ROS). Superoxide (O 2 •−) is produced by NADPH oxidase, xanthine oxidase, nitric oxide synthase (NOS), lipoxygenase, and mitochondrial enzymes.Superoxide is converted by superoxide dismutase (SOD) to H 2 O 2, which, in turn, is reduced to water by catalase, glutathione peroxidases (GPx), and peroxiredoxins (Prx).

    Get Price
  • Vascular endothelial growth factor induces manganese ...

    2001-9-17u2002·u2002Vascular endothelial growth factor (VEGF) is a potent vascular endothelial cell-specific mitogen that modulates endothelial cell function. In the present study, we show that VEGF induces manganese-superoxide dismutase (MnSOD) mRNA and protein in human coronary artery endothelial cells (HCAEC) and pulmonary artery endothelial cells.

    Get Price
  • β-Lactoglobulin Heptapeptide Reduces Oxidative Stress in ...

    2019-11-12u2002·u2002Peptides derived from buffalo dairy products possess multiple healthy properties that cannot be exerted as long as they are encrypted in parent proteins. To evaluate the biological activities of encrypted peptide sequences from buffalo ricotta cheese, we performed a simulated gastrointestinal (GI) digestion. Chemical and pharmacological characterization of the digest led to the identification ...

    Get Price
  • The Separation of Antler Polypeptide and Its Effects on ...

    2020-10-7u2002·u2002Background . Colla Cornus Cervi (CCC) has been used as a traditional Chinese medicine in the treatment of osteoporosis and osteonecrosis of the femoral head. However, the bioavailability of CCC is seriously limited owing to its large molecular weight and complex ingredients. In the present study, antler polypeptide was separated from CCC, and the effects of antler polypeptide on rat bone ...

    Get Price
  • ConferenceSeries LLC LTD

    Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 1000+ Conferences, 1000+ Symposiums and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.. Explore and learn more about …

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  • Artificial Organs 2009: A Year in Review

    The circuit was primed with 1000 mL heparinized human packed red blood cells and 1000 mL lactated Ringer's solution (total volume 2000 mL, corrected hematocrit 26-28%).

    Get Price
  • Extracellular superoxide dismutase and its role in cancer ...

    2017-11-1u2002·u2002The superoxide dismutase family plays an essential physiological role in mitigating deleterious effects of ROS. Due to the compartmentalization of ROS signaling, EcSOD, the only superoxide dismutase in the extracellular space, has unique characteristics and functions in cellular signal transduction.

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  • Sensitivity of Pseudomonas syringae to Bovine Lactoferrin ...

    2016-8-30u2002·u2002Introduction. Lactoferrin (Lf) can find in the secondary granules of neutrophils and blood, as well as diverse mammalian secretions such as saliva, rhinorrhea, tears, and milk (Shimazaki, 2000).Antimicrobial activity of Lf was first reported by Reiter and Oram (1967).The antimicrobial effect of Lf is related to its iron-chelating ability and also to a direct effect on the bacterial cell ...

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  • Low Activity of Manganese Superoxide Dismutase

    Manganese Superoxide Dismutase in Lung Cancer Patients with a Smoking History Asian Pacific Journal of Cancer Prevention, Vol 12, 20113051 the mixture was left on ice for 5 minutes.

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  • Myrtol improves post‑traumatic knee osteoarthritis by ...

    superoxide dismutase (SOD), ROS and TGF‑β1 levels. A total of 200 µl of blood was collected from mice in each group immediately following sacrifice and separated using centrifuga-tion at 5,000 x g for 10 min at 4˚C. Blood serum was acquired and analyzed for TNF-α (cat. no.-ECL -M0047c), IL-6 (cat.

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  • Hydrostatic pressure-generated reactive oxygen species ...

    2018-11-19u2002·u2002Cells were expanded on standard cell culture dishes (STARLAB, Hamburg, Germany) in a humidified incubator at 37 °C and 5% CO 2. To avoid premature differentiation, cells were subcultured at …

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  • ALOE VERA IN THE CONTROL OF OXIDATIVE STRESS

    2011-3-6u2002·u2002movement of several types of white blood cells (leukocytes) into the injured or infected tissues. Free radicals and other ROS are thought to play a role in the inflammatory response. Specific antioxidant enzymes, such as Superoxide Dismutase (SOD) or catalase (CAT) attenuate the injury and inflammation in animal models of ischemia/reperfusion,

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  • Oxidative stress-mediated genotoxicity of malathion in ...

    2020-1-1u2002·u20021. Introduction. Malathion (diethyl, 2-[(dimethoxyphosphinothioyl]butanedioate) is a non-systemic broad-spectrum organophosphate pesticide widely used for the control of insect pests of crops, gardens, household products, ectoparasites on animals, and in public health pest-eradication programmes [].In India, malathion production was more than 3000 metric tons in 2017-18 [].

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  • BLACKMORES Vitamins & Supplements - Australia's #1 ...

    Manganese is an essential trace mineral that is a co-factor in many of the body's enzymes, including superoxide dismutase. Manganese can be found in hazelnuts, blackberries, pineapple, lentils, beans and whole grains. Zinc amino acid chelate (zinc 15 mg): 75 mg. Zinc is an essential trace element that plays a role in every living cell in the body.

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  • Suppression of oxidative stress in endothelial progenitor ...

    EXPERIMENTAL AND THERAPEUTIC MEDICINE 11: 2163-2170, 2016 2165 compartment. EPCs (1x105 cells) in 100 µl chemotaxis buffer were added to the upper compartment. Subsets of cells were

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  • Estimation of toxic elements in the samples of different ...

    2015-3-4u2002·u2002Cigarette smoking interferes with the metal homeostasis of the human body, which plays a crucial role for maintaining the health. A significant flux of heavy metals, among other toxins, reaches the lungs through smoking. In the present study, the relationship between toxic element (TE) exposure via cigarette smoking and rheumatoid arthritis incidence in population living in Dublin, Ireland, is ...

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  • The structural biochemistry of the superoxide dismutases

    2021-7-24u2002·u20023. Cu,ZnSOD. In 1938, Mann and Keilin [] isolated a bovine erythrocyte protein with a blue color contributed by bound copper.They termed the ~31.5 kDa protein hemocuprein. In the 1950s, human homologues of erythrocuprein were isolated from erythrocytes [70,71] and perhaps more pertinent to ALS, cerebrocuprein from the brain [].In 1969, 30 years after the initial isolation, McCord and Fridovich ...

    Get Price
  • Extracellular Superoxide Dismutase: Growth Promoter or ...

    2016-5-12u2002·u2002Extracellular superoxide dismutase (SOD3) gene transfer to tissue damage results in increased healing, increased cell proliferation, decreased apoptosis, and decreased inflammatory cell infiltration. At molecular level, in vivo SOD3 overexpression reduces superoxide anion () concentration and increases mitogen kinase activation suggesting that ...

    Get Price
  • Effect of dietary bovine lactoferrin on lipid peroxidation ...

    The technology of producing bovine lactoferrin on a factory scale was established over 20 years ago. ... A method is described for the estimation of red cell superoxide dismutase (erythrocuprein ...

    Get Price
  • Evaluation of Superoxide Dismutase Enzyme Activity of ...

    2021-7-13u2002·u2002growth, mutagenesis and cell death, the critical damaging effects being on DNA and enzymes. 4 The antioxidant system includes enzymatic and non-enzymatic antioxidant components. Superoxide dismutase (SOD), one of the main antioxidant enzymes, catalyses the dismutation of highly reactive superoxide anions to hydrogen peroxide, a

    Get Price
  • Superoxide Dismutases: Role in Redox Signaling, Vascular ...

    2011-9-15u2002·u2002Generation and metabolism of reactive oxygen species (ROS). Superoxide (O 2 •−) is produced by NADPH oxidase, xanthine oxidase, nitric oxide synthase (NOS), lipoxygenase, and mitochondrial enzymes.Superoxide is converted by superoxide dismutase (SOD) to H 2 O 2, which, in turn, is reduced to water by catalase, glutathione peroxidases (GPx), and peroxiredoxins (Prx).

    Get Price
  • Vascular endothelial growth factor induces manganese ...

    2001-9-17u2002·u2002Vascular endothelial growth factor (VEGF) is a potent vascular endothelial cell-specific mitogen that modulates endothelial cell function. In the present study, we show that VEGF induces manganese-superoxide dismutase (MnSOD) mRNA and protein in human coronary artery endothelial cells (HCAEC) and pulmonary artery endothelial cells.

    Get Price
  • β-Lactoglobulin Heptapeptide Reduces Oxidative Stress in ...

    2019-11-12u2002·u2002Peptides derived from buffalo dairy products possess multiple healthy properties that cannot be exerted as long as they are encrypted in parent proteins. To evaluate the biological activities of encrypted peptide sequences from buffalo ricotta cheese, we performed a simulated gastrointestinal (GI) digestion. Chemical and pharmacological characterization of the digest led to the identification ...

    Get Price
  • The Separation of Antler Polypeptide and Its Effects on ...

    2020-10-7u2002·u2002Background . Colla Cornus Cervi (CCC) has been used as a traditional Chinese medicine in the treatment of osteoporosis and osteonecrosis of the femoral head. However, the bioavailability of CCC is seriously limited owing to its large molecular weight and complex ingredients. In the present study, antler polypeptide was separated from CCC, and the effects of antler polypeptide on rat bone ...

    Get Price
  • ConferenceSeries LLC LTD

    Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 1000+ Conferences, 1000+ Symposiums and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.. Explore and learn more about …

    Get Price
  • Artificial Organs 2009: A Year in Review

    The circuit was primed with 1000 mL heparinized human packed red blood cells and 1000 mL lactated Ringer's solution (total volume 2000 mL, corrected hematocrit 26-28%).

    Get Price
  • The structural biochemistry of the superoxide dismutases

    2021-7-24u2002·u20023. Cu,ZnSOD. In 1938, Mann and Keilin [] isolated a bovine erythrocyte protein with a blue color contributed by bound copper.They termed the ~31.5 kDa protein hemocuprein. In the 1950s, human homologues of erythrocuprein were isolated from erythrocytes [70,71] and perhaps more pertinent to ALS, cerebrocuprein from the brain [].In 1969, 30 years after the initial isolation, McCord and Fridovich ...

    Get Price
  • Extracellular Superoxide Dismutase: Growth Promoter or ...

    2016-5-12u2002·u2002Extracellular superoxide dismutase (SOD3) gene transfer to tissue damage results in increased healing, increased cell proliferation, decreased apoptosis, and decreased inflammatory cell infiltration. At molecular level, in vivo SOD3 overexpression reduces superoxide anion () concentration and increases mitogen kinase activation suggesting that ...

    Get Price
  • Effect of dietary bovine lactoferrin on lipid peroxidation ...

    The technology of producing bovine lactoferrin on a factory scale was established over 20 years ago. ... A method is described for the estimation of red cell superoxide dismutase (erythrocuprein ...

    Get Price
  • Evaluation of Superoxide Dismutase Enzyme Activity of ...

    2021-7-13u2002·u2002growth, mutagenesis and cell death, the critical damaging effects being on DNA and enzymes. 4 The antioxidant system includes enzymatic and non-enzymatic antioxidant components. Superoxide dismutase (SOD), one of the main antioxidant enzymes, catalyses the dismutation of highly reactive superoxide anions to hydrogen peroxide, a

    Get Price
  • Superoxide Dismutases: Role in Redox Signaling, Vascular ...

    2011-9-15u2002·u2002Generation and metabolism of reactive oxygen species (ROS). Superoxide (O 2 •−) is produced by NADPH oxidase, xanthine oxidase, nitric oxide synthase (NOS), lipoxygenase, and mitochondrial enzymes.Superoxide is converted by superoxide dismutase (SOD) to H 2 O 2, which, in turn, is reduced to water by catalase, glutathione peroxidases (GPx), and peroxiredoxins (Prx).

    Get Price
  • Vascular endothelial growth factor induces manganese ...

    2001-9-17u2002·u2002Vascular endothelial growth factor (VEGF) is a potent vascular endothelial cell-specific mitogen that modulates endothelial cell function. In the present study, we show that VEGF induces manganese-superoxide dismutase (MnSOD) mRNA and protein in human coronary artery endothelial cells (HCAEC) and pulmonary artery endothelial cells.

    Get Price
  • β-Lactoglobulin Heptapeptide Reduces Oxidative Stress in ...

    2019-11-12u2002·u2002Peptides derived from buffalo dairy products possess multiple healthy properties that cannot be exerted as long as they are encrypted in parent proteins. To evaluate the biological activities of encrypted peptide sequences from buffalo ricotta cheese, we performed a simulated gastrointestinal (GI) digestion. Chemical and pharmacological characterization of the digest led to the identification ...

    Get Price
  • The Separation of Antler Polypeptide and Its Effects on ...

    2020-10-7u2002·u2002Background . Colla Cornus Cervi (CCC) has been used as a traditional Chinese medicine in the treatment of osteoporosis and osteonecrosis of the femoral head. However, the bioavailability of CCC is seriously limited owing to its large molecular weight and complex ingredients. In the present study, antler polypeptide was separated from CCC, and the effects of antler polypeptide on rat bone ...

    Get Price
  • ConferenceSeries LLC LTD

    Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 1000+ Conferences, 1000+ Symposiums and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.. Explore and learn more about …

    Get Price
  • Artificial Organs 2009: A Year in Review

    The circuit was primed with 1000 mL heparinized human packed red blood cells and 1000 mL lactated Ringer's solution (total volume 2000 mL, corrected hematocrit 26-28%).

    Get Price
  • VEGF Stimulates the ERK 1/2 Signaling Pathway and ...

    2009-2-19u2002·u2002Cells were transfected with VEGF small interference RNA. A terminal deoxynucleotidyl transferase-mediated uridine 5′-triphosphate-biotin nick end labeling (TUNEL) assay and DNA fragmentation assay were used on mouse endothelial cells that overexpress copper/zinc-superoxide dismutase (SOD1).

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  • Eukaryotic copper-only superoxide dismutases (SODs): A new ...

    2018-3-30u2002·u2002The copper-containing superoxide dismutases (SODs) represent a large family of enzymes that participate in the metabolism of reactive oxygen species by disproportionating superoxide anion radical to oxygen and hydrogen peroxide. Catalysis is driven by the redox-active copper ion, and in most cases, SODs also harbor a zinc at the active site that enhances copper …

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  • Genetic requirement of p47 phox for superoxide production ...

    2000-12-8u2002·u2002To prepare cells for superoxide assays, microglial cells derived from wild-type or p47 phox-deficient mice were separated from more adherent fibroblast-like cells in the mixed glial cell cultures at 100% confluence by rotary shaking at 200 rpm for 1 h at room temperature. Some of the fibroblast-like cells were dislodged by shaking as well, but ...

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  • Epicatechin Gallate Protects HBMVECs from Ischemia ...

    2019-7-30u2002·u2002Superoxide dismutase (SOD) serves a key antioxidant role in cells considering superoxide as one of the principal reac-tive oxygen species. Malondialdehyde (MDA) is a marker for oxidative stress which results from lipid peroxidation of polyunsaturated fatty acids. Dysfunction of SOD and MDA aggravate oxidative stress and I/R injury [3–5]. LDH is

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  • Superoxide Dismutase 2 (SOD2) in Vascular Calcification: A ...

    2021-2-26u2002·u2002Vascular calcification (VC) describes the pathophysiological phenotype of calcium apatite deposition within the vascular wall, leading to vascular stiffening and the loss of compliance. VC is never benign; the presence and severity of VC correlate closely with the risk of myocardial events and cardiovascular mortality in multiple at-risk populations such as patients with diabetes …

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  • Department of Dermatology and Allergic Diseases Ulm ...

    SOD Superoxide dismutase SSC Side scatter Syk Spleen tyrosine kinase τ2 Fluorescence lifetime of enzyme bound NADPH TBS(T) Tris-buffered saline (+ Tween 20) TGF-β(-RI/II) Transforming growth factor-beta (receptor I/II) Th Helper T-cell TSP Thrombospondin VCAM Vascular cell adhesion molecule VEGF Vascular endothelial growth factor

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  • Suppression of oxidative stress in endothelial progenitor ...

    2016-4-8u2002·u2002Myocardial infarction is a major contributor to morbidity and mortality in diabetes, which is characterized by inadequate angiogenesis and consequent poor blood reperfusion in the diabetic ischemic heart. The aim of the present study was to investigate the effect that oxidative stress in endothelial progenitor cells (EPCs) has on cardiac angiogenesis in diabetic mice.

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  • Growth Factor Multiplex Assays

    Growth Factor Multiplex Assays. Your search returned 98 Growth Factor Multiplex Growth Factor Multiplex Assays across 4 suppliers. Select up to 5 products from below to compare or request more information.

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  • Regulation of Dendrobium Polysaccharides on Proliferation ...

    2021-6-14u2002·u2002protect islet cells, resist calcium overload, and protect and repair cells [10–12]. Therefore, we speculated that PDC might regulate the oxidative stress of human umbilical vein endothelial cells (HUVECs) under high glucose environment, promote the proliferation of HUVECs, and thus exert its effect on pro-tecting endothelial cells.

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  • Effects of dietary supplementation with an expressed ...

    During weaning, piglets are exposed to many stressors, including separation from the sow and the loss of sow milk. These abrupt changes in the piglets' diet often result in disturbances in digestive function and gastrointestinal disease (Reference Pluske, Hampson and Williams 1).Post-weaning diarrhoea is a multifactorial condition that occurs after weaning, but is characterised by the ...

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