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  • Roles of prostaglandin F2alpha and hydrogen peroxide in ...

    2012-10-26u2002·u2002The cells were pooled and cultured in endothelial cell (EC) growth medium (MV 2; C22121; Promo Cell, Heidelberg, Germany) at 37°C in a humidified atmosphere of 5% CO 2 in air. Only colonies with a homogeneous cell population were removed with a pipette and cultured in collagen-coated 25 cm 2 culture flasks (690175; Greiner Bio-One ...

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  • Superoxide Dismutase from bovine erythrocytes - Sigma

    Superoxide Dismutase from bovine erythrocytes is a metalloprotein which disproportionates superoxide anion radicals. It is a 31.5 kDa copper binding protein and displays a conserved domain and fold. It is a homodimer with one copper and zinc ion per subunit and has antiparallel 'greek-key' β barrel fold.

    Get Price
  • Superoxide Dismutase bovine recombinant, expressed in E ...

    Superoxide Dismutase bovine recombinant, expressed in E. coli, lyophilized powder, ≥2500 units/mg protein, ≥90% (SDS-PAGE); CAS Number: 9054-89-1; EC Number: 232-943-0; Synonyms: Superoxide Dismutase 1 bovine,SOD1,Superoxide: superoxide oxidoreductase,SOD,CU/ZN-SOD; find Sigma-Aldrich-S9697 MSDS, related peer-reviewed papers, technical documents, similar products & more at …

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  • Roles of prostaglandin F2alpha and hydrogen peroxide in ...

    2012-10-26u2002·u2002Roles of prostaglandin F2alpha and hydrogen peroxide in the regulation of Copper/Zinc superoxide dismutase in bovine corpus luteum and luteal endothelial cells. Hai V Vu Laboratory of Reproductive Physiology, Graduate School of Natural Science and Technology, Okayama University, Okayama, 700-8530, Japan.

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  • Long term safety and immunological effects of a ...

    2018-7-21u2002·u2002Bovine stroma-free hemoglobin solution preparation Stroma-free hemoglobin (SFHb) solution is the red blood cell content with the removal of lipid membrane by organic solvent. To separate red blood cells, the heparinized bovine whole blood is centrifuged at 4500g at 4°C for 30 minutes. Remove the plasma layer carefully by vacuum suction using

    Get Price
  • Protection of Bovine Mammary Epithelial Cells from ...

    The mammary epithelial cells (MECs) of high-producing dairy cows are likely to be subject to oxidative stress (OS) due to the intensive cell metabolism. The objectives of this study were to investigate the cytoprotective effects of resveratrol against hydrogen peroxide- (H 2 O 2 -) induced OS in cultured bovine …

    Get Price
  • Ras-induced reactive oxygen species promote growth

    2010-2-11u2002·u2002Excessive production of ROS (comprising mainly superoxide and H 2 O 2) is a common feature of malignant disease including leukemia. 9,10 Common leukemia-associated abnormalities such as activated Ras, 9,11 activated FMS-like tyrosine kinase 3, 12 and BCR-ABL 13 are associated particularly with overproduction of ROS. One consequence of this is an increase in DNA damage, 14 …

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  • Vascular endothelial growth factor induces manganese ...

    2001-9-17u2002·u2002Vascular endothelial growth factor (VEGF) is a potent vascular endothelial cell-specific mitogen that modulates endothelial cell function. In the present study, we show that VEGF induces manganese-superoxide dismutase (MnSOD) mRNA and protein in human coronary artery endothelial cells (HCAEC) and pulmonary artery endothelial cells.

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  • Mesenchymal Stem Cell Therapy Protects Lungs from ...

    2016-11-14u2002·u2002Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression. Diana Klein 1 Institute of Cell Biology (Cancer Research), University Hospital, University of Duisburg-Essen, Essen, Germany .

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  • The structural biochemistry of the superoxide dismutases

    2021-7-24u2002·u2002The second thought that superoxide was unlikely to exist in cells, or to interact with cellular substances, or that superoxide dismutase did not function to remove superoxide, and that SOD activity was inhibited by phosphate [7,8,39,43,289]. However, due to the many breakthroughs in SOD research, initiated by Fridovich and McCord and which we ...

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  • (PDF) Superoxide and superoxide dismutase

    Sedimentation velocity schlieren patterns of bovine superoxide dismutase. ml in 0.1 Y NaCl buffered at pH 7.0 with potassium phosphate. Protein concentration was 7.35 mg per

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  • The Aktâ FoxO3aâ manganese superoxide dismutase

    cell growth and cell survival. Phosphoinositide 3-kinase phosphorylates and activates Akt. Activated Akt can phosphorylate several downstream proteins, including Glycogen Synthase Kinase 3-β, Forkhead (FoxO) transcription factors and tuberous sclerosis 1 and 2, to control cell growth, cell survival and protein synthesis (Garcia et al.2006; Kim ...

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  • Mesenchymal Stem Cell Therapy Protects Lungs from ...

    2016-11-14u2002·u2002Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression. Diana Klein 1 Institute of Cell Biology (Cancer Research), University Hospital, University of Duisburg-Essen, Essen, Germany .

    Get Price
  • Long term safety and immunological effects of a ...

    2018-7-21u2002·u2002Bovine stroma-free hemoglobin solution preparation Stroma-free hemoglobin (SFHb) solution is the red blood cell content with the removal of lipid membrane by organic solvent. To separate red blood cells, the heparinized bovine whole blood is centrifuged at 4500g at 4°C for 30 minutes. Remove the plasma layer carefully by vacuum suction using

    Get Price
  • Frontiers

    2021-2-25u2002·u2002Superoxide dismutase 3 (SOD3), a well-known antioxidant has been shown to possess immunomodulatory properties through inhibition of T cell differentiation. However, the underlying inhibitory mechanism of SOD3 on T cell differentiation is not well understood. In this study, we investigated the effect of SOD3 on anti-CD3/CD28- or phorbol myristate acetate (PMA) and ionomycin (ION)-mediated ...

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  • Superoxide Dismutases: Role in Redox Signaling, Vascular ...

    2011-9-15u2002·u2002Generation and metabolism of reactive oxygen species (ROS). Superoxide (O 2 •−) is produced by NADPH oxidase, xanthine oxidase, nitric oxide synthase (NOS), lipoxygenase, and mitochondrial enzymes.Superoxide is converted by superoxide dismutase (SOD) to H 2 O 2, which, in turn, is reduced to water by catalase, glutathione peroxidases (GPx), and peroxiredoxins (Prx).

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  • Differential effects of superoxide dismutase and ...

    2015-3-21u2002·u2002Reactive oxygen species (ROS) such as superoxide and hydrogen peroxide (H 2 O 2) are produced by all aerobic cells during metabolism under normal oxygen conditions.Physiologically, ROS can be cleared from the cellular system through either enzymatic or non-enzymatic pathways such as glutathione (GSH), thioredoxin (Trx), superoxide dismutase (SOD), catalase, and peroxidases.

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  • (PDF) Differential effects of superoxide dismutase and ...

    2015-3-21u2002·u2002Effects of MnTmPyP and EUK 134 on breast cancer cell cycle progression. MCF-7 or MDA-MB-231 cells were seeded in 10-cm plate and incubated …

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  • Novel Role of Mitochondrial Manganese Superoxide

    2015-3-30u2002·u2002Leukemia Inhibitory Factor (LIF)/Signal transducer and activator of transcription 3 (STAT3) signaling pathway maintains the stemness and pluripotency of mouse embryonic stem cells (mESCs).

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  • The Role of Manganese Superoxide Dismutase in the

    No correlation could be found between cell growth and levels of copper/zinc superoxide dismutase, catalase, or glutathione peroxidase. Enforced expression of MnSOD by adenovirus transfection in the rapid growing cell line MIA PaCa-2 increased MnSOD immunoreactivity and MnSOD activity and decreased growth rate.

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  • Superoxide Dismutase (SOD) Colorimetric Activity Kit

    The Superoxide Dismutase Activity research-use-only kit is a colorimetric activity assay designed for the quantification and detection of superoxide dismutase activity in serum, plasma, cells, tissues and erythrocyte lysates.This complete, ready-to-use kit includes clear 96-well plate(s), superoxide

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  • Superoxide dismutase-3 promotes full expression of the

    2004-7-1u2002·u2002To maintain O 2 homeostasis, a number of genes are up-regulated at low O 2 tension via signaling that activates transcription (eg, via hypoxia-inducible transcription factor 1 [HIF-1]). HIF-1 is crucial in sensing hypoxia and integrating the adaptive response via transcription of O 2-sensitive genes. 12,13 The physiologic factors that link O 2 availability to transcription relate broadly to ...

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  • High serum superoxide dismutase activity improves ...

    superoxide dismutase (SOD), and they play a very critical role in cellular defense against oxidative damage (11). In 1968, McCord and Fridovich found a protein in bovine red blood cells that can catalyze the dismutation of the superoxide (O 2) radical into either hydrogen peroxide (H 2O 2) or ordinary molecular oxygen (O 2) (12). They named ...

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  • The Aktâ FoxO3aâ manganese superoxide dismutase

    cell growth and cell survival. Phosphoinositide 3-kinase phosphorylates and activates Akt. Activated Akt can phosphorylate several downstream proteins, including Glycogen Synthase Kinase 3-β, Forkhead (FoxO) transcription factors and tuberous sclerosis 1 and 2, to control cell growth, cell survival and protein synthesis (Garcia et al.2006; Kim ...

    Get Price
  • Manganese superoxide dismutase deficiency triggers ...

    2014-11-3u2002·u2002Manganese superoxide dismutase (MnSOD) is a mitochondrially localized primary antioxidant enzyme, known to be essential for the survival of aerobic life …

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  • Novel Role of Mitochondrial Manganese Superoxide

    2015-3-30u2002·u2002Leukemia Inhibitory Factor (LIF)/Signal transducer and activator of transcription 3 (STAT3) signaling pathway maintains the stemness and pluripotency of mouse embryonic stem cells (mESCs).

    Get Price
  • Ras-induced reactive oxygen species promote growth

    2010-2-11u2002·u2002Excessive production of ROS (comprising mainly superoxide and H 2 O 2) is a common feature of malignant disease including leukemia. 9,10 Common leukemia-associated abnormalities such as activated Ras, 9,11 activated FMS-like tyrosine kinase 3, 12 and BCR-ABL 13 are associated particularly with overproduction of ROS. One consequence of this is an increase in DNA damage, 14 …

    Get Price
  • Protection of Bovine Mammary Epithelial Cells from ...

    The mammary epithelial cells (MECs) of high-producing dairy cows are likely to be subject to oxidative stress (OS) due to the intensive cell metabolism. The objectives of this study were to investigate the cytoprotective effects of resveratrol against hydrogen peroxide- (H 2 O 2 -) induced OS in cultured bovine …

    Get Price
  • Promotion of Survival and Engraftment of Transplanted ...

    2016-7-7u2002·u20021. Introduction. Cell therapy is an innovative approach for the treatment of some acute and chronic degenerative conditions [].Transplanted cells may promote tissue regeneration through different mechanisms, including cell differentiation, cell fusion and paracrine effects via the secretion of various cytokines, growth factors and/or microvesicles.

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  • Extracellular superoxide dismutase is a growth regulatory ...

    2008-12-23u2002·u2002Extracellular superoxide dismutase (SOD3) gene therapy has been shown to attenuate tissue damages and to improve the recovery of the tissue injuries, but the cellular events delivering the therapeutic response of the enzyme are not well defined.In the current work, we overexpressed SOD3 in rat hindlimb ischemia model to study the signal transduction and injury healing following the sod3 gene ...

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  • Overexpression of Extracellular Superoxide Dismutase ...

    2009-8-1u2002·u2002Increased expression of heparanase stimulates the progression of various human cancers, including breast cancer. Therefore, a deeper understanding of the mechanisms involved in regulating heparanase is critical in developing effective treatments for heparanase-overexpressing cancers. In this study, we investigated the potential use of extracellular superoxide dismutase (EcSOD) to enhance …

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  • Klotho enhances FoxO3-mediated manganese superoxide ...

    2017-8-3u2002·u2002HK-2 cells from an immortalized human proximal tubular epithelial cell line were grown in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine …

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  • Long term safety and immunological effects of a ...

    2018-7-21u2002·u2002Bovine stroma-free hemoglobin solution preparation Stroma-free hemoglobin (SFHb) solution is the red blood cell content with the removal of lipid membrane by organic solvent. To separate red blood cells, the heparinized bovine whole blood is centrifuged at 4500g at 4°C for 30 minutes. Remove the plasma layer carefully by vacuum suction using

    Get Price
  • Serum lipid peroxide level and blood superoxide

    We studied whether lead exposure increased the serum lipid peroxide (LPO) level and inhibited blood superoxide dismutase (SOD) activity in workers with occupational exposure to lead and rats injected with lead. We examined the following subjects: (1) manual workers (712 males) from 18 to 59-years-old in steel production with occupational exposure to lead, (2) office workers (155 males) without ...

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  • The role of manganese superoxide dismutase in the

    To that end, it has been demonstrated that a mild increase in intracellular superoxide (O 2 •-) levels can either promote signal transduction favoring cell proliferation or buffer cancer cells ...

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  • Mesenchymal Stem Cell Therapy Protects Lungs from ...

    2016-11-14u2002·u2002Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression. Diana Klein 1 Institute of Cell Biology (Cancer Research), University Hospital, University of Duisburg-Essen, Essen, Germany .

    Get Price
  • SciELO - Brasil - High serum superoxide dismutase activity ...

    In 1968, McCord and Fridovich found a protein in bovine red blood cells that can catalyze the dismutation of the superoxide (O 2) radical into either hydrogen peroxide (H 2 O 2) or ordinary molecular oxygen (O 2) (12 12. McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for …

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  • Biomimetic Superoxide Dismutase Stabilized by ...

    The cells are then 3D cultured in the functional hydrogel, and the releasing superoxide anion (O2•‒) is detected in situ by a cascade superoxide dismutase and horseradish peroxidase-based ...

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  • Importance of superoxide dismutases A and M for

    1 INTRODUCTION. Cystic fibrosis (CF) is a genetic disorder that affects more than 70,000 people of the Caucasian population worldwide (Cutting, 2015).In CF patients, the ion and water transport across epithelial membranes is dysregulated, which provokes the accumulation of a thick mucus in different organs, including the airways, and impairs important immune defence mechanisms, thereby ...

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  • Roles of prostaglandin F2alpha and hydrogen peroxide in ...

    2012-10-26u2002·u2002The cells were pooled and cultured in endothelial cell (EC) growth medium (MV 2; C22121; Promo Cell, Heidelberg, Germany) at 37°C in a humidified atmosphere of 5% CO 2 in air. Only colonies with a homogeneous cell population were removed with a pipette and cultured in collagen-coated 25 cm 2 culture flasks (690175; Greiner Bio-One ...

    Get Price
  • Superoxide Dismutase from bovine erythrocytes - Sigma-Aldrich

    Superoxide Dismutase from bovine erythrocytes is a metalloprotein which disproportionates superoxide anion radicals. It is a 31.5 kDa copper binding protein and displays a conserved domain and fold. It is a homodimer with one copper and zinc ion per subunit and has antiparallel 'greek-key' β barrel fold.

    Get Price
  • Superoxide Dismutase bovine recombinant, expressed in E ...

    Superoxide Dismutase bovine recombinant, expressed in E. coli, lyophilized powder, ≥2500 units/mg protein, ≥90% (SDS-PAGE); CAS Number: 9054-89-1; EC Number: 232-943-0; Synonyms: Superoxide Dismutase 1 bovine,SOD1,Superoxide: superoxide oxidoreductase,SOD,CU/ZN-SOD; find Sigma-Aldrich-S9697 MSDS, related peer-reviewed papers, technical documents, similar …

    Get Price
  • Roles of prostaglandin F2alpha and hydrogen peroxide in ...

    2012-10-26u2002·u2002Roles of prostaglandin F2alpha and hydrogen peroxide in the regulation of Copper/Zinc superoxide dismutase in bovine corpus luteum and luteal endothelial cells. Hai V Vu Laboratory of Reproductive Physiology, Graduate School of Natural Science and Technology, Okayama University, Okayama, 700-8530, Japan.

    Get Price
  • Long term safety and immunological effects of a ...

    2018-7-21u2002·u2002Bovine stroma-free hemoglobin solution preparation Stroma-free hemoglobin (SFHb) solution is the red blood cell content with the removal of lipid membrane by organic solvent. To separate red blood cells, the heparinized bovine whole blood is centrifuged at 4500g at 4°C for 30 minutes. Remove the plasma layer carefully by vacuum suction using

    Get Price
  • Protection of Bovine Mammary Epithelial Cells from ...

    The mammary epithelial cells (MECs) of high-producing dairy cows are likely to be subject to oxidative stress (OS) due to the intensive cell metabolism. The objectives of this study were to investigate the cytoprotective effects of resveratrol against hydrogen peroxide- (H 2 O 2 -) induced OS in cultured bovine MECs (MAC-T).

    Get Price
  • Ras-induced reactive oxygen species promote growth factor ...

    2010-2-11u2002·u2002Excessive production of ROS (comprising mainly superoxide and H 2 O 2) is a common feature of malignant disease including leukemia. 9,10 Common leukemia-associated abnormalities such as activated Ras, 9,11 activated FMS-like tyrosine kinase 3, 12 and BCR-ABL 13 are associated particularly with overproduction of ROS. One consequence of this is an increase in DNA damage, …

    Get Price
  • Vascular endothelial growth factor induces manganese ...

    2001-9-17u2002·u2002Vascular endothelial growth factor (VEGF) is a potent vascular endothelial cell-specific mitogen that modulates endothelial cell function. In the present study, we show that VEGF induces manganese-superoxide dismutase (MnSOD) mRNA and protein in human coronary artery endothelial cells (HCAEC) and pulmonary artery endothelial cells.

    Get Price
  • Mesenchymal Stem Cell Therapy Protects Lungs from ...

    2016-11-14u2002·u2002Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression. Diana Klein 1 Institute of Cell Biology (Cancer Research), University Hospital, University of Duisburg-Essen, Essen, Germany .

    Get Price
  • R&D Systems: Products & Services for Cell Biology Research

    R&D Systems is a global resource for cell biology. Find quality proteins, antibodies, ELISA kits, laboratory reagents, and tools.

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  • Discrete Generation of Superoxide and Hydrogen Peroxide

    2002-1-7u2002·u2002Antibodies to phosphorylated p44/42 ERK and pan-specific anti-ERK1/2 were obtained from Cell Signaling. Antibodies to manganese superoxide dismutase (MnSOD; reference 17) and TPx II have been described previously, while anti-copper/zinc superoxide dismutase (CuZnSOD) was supplied by UBI, and anti-catalase was obtained from Calbiochem. The ...

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  • Dual Role of Superoxide Dismutase 2 Induced in Activated ...

    2015-9-11u2002·u2002Background: The redox state can affect the proinflammatory responses of microglia.Results: Superoxide dismutase 2 (SOD2) knockdown in activated microglia increased the production of reactive oxygen species (ROS) as well as inflammatory cytokines.Conclusion: SOD2 negatively regulates the inflammatory cytokine expression via ROS elimination.Significance: Our findings demonstrate a novel ...

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  • Nanoparticles for Targeted Delivery of Antioxidant

    2013-2-6u2002·u2002Superoxide dismutase is of special interest as a potential therapeutic agent for secondary CNSI because of its high ROS degradation rate. 13 It converts superoxide, the most toxic ROS, to much less reactive peroxide. 14 Overexpression of SOD1 has been shown to attenuate apoptotic cells death. 15 However, exogenous SOD has shown no efficacy in ...

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  • The Protective Effect of a Metallic Selenopeptide with ...

    2014-2-15u2002·u2002A 65-mer peptide (Se–CuZn–65P) is an enzyme mimic with antioxidant activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX). The metallic selenopeptide imitate was obtained through a single protein production system and cysteine auxotrophic expression technique, and it enters cells in the assistance of the trans-activator of transcription peptide. Because Se–CuZn–65P was ...

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  • Therapeutic effect of lecithinized superoxide dismutase on ...

    2010-3-1u2002·u2002Idiopathic pulmonary fibrosis (IPF) is thought to involve inflammatory infiltration of leukocytes, lung injury induced by reactive oxygen species (ROS), in particular superoxide anion, and fibrosis (collagen deposition). No treatment has been shown to improve definitively the prognosis for IPF patients. Superoxide dismutase (SOD) catalyzes the dismutation of superoxide anion to hydrogen ...

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  • Effect of the flavonoid baicalin on the proliferative ...

    2021-10-15u2002·u2002Background High-yielding dairy cows are prone to oxidative stress due to the high metabolic needs of homeostasis and milk production. Oxidative stress and inflammation are tightly linked; therefore, anti-inflammatory and/or natural antioxidant compounds may help improve mammary cell health. Baicalin, one of the major flavonoids in Scutellaria baicalensis, has natural antioxidant and anti ...

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  • Autophagy is involved in the replication of H9N2

    2021-1-18u2002·u2002A virus-infected cells and mice, and results in signicant damage to respiratory tissues [6]. e increase in ROS levels by IAV-induced superoxide dismutase 1 (SOD1) downregulation appears to inuence viral replication [7]. e antioxidant treatment of inuenza virus-infected cells has been shown to result in a lower viral titer, sup-

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  • Estimation of toxic elements in the samples of different ...

    2018-7-19u2002·u2002prevents neoplastic cell growth, is involved in mitotic cell division, DNA, and RNA repair. Zinc plays an important role in nucleic acid synthesis, transcription, and translation as a cofactor for some of the enzymes involved and may therefore participate in a broad range of metabolic activities in the bone.

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  • Reduced graphene oxide: nanotoxicological profile in rats ...

    2016-6-24u2002·u2002Graphene is a single layer of densely packed, regular sp 2-bonded carbon atoms arranged in a hexagonally two-dimensional structure [].Graphene and derivatives, such as graphene oxide (GO) and reduced graphene oxide (rGO), have attracted significant interest in many technological fields due to their unique electronic, optical, magnetic, thermal and mechanical properties.

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  • Chrysin

    2021-10-25u2002·u2002Chrysin, a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant, anti-inflammation, anti-cancer, hepatoprotective, and anti-oxidation properties. Chrysin induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells; it prevented the development of DN in HFD/STZ-induced type 2 diabetic rats through anti-inflammatory effects in the ...

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